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Addiction is a Reward Deficit and Stress Surfeit Disorder
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Evidence for addiction-like behavior in the rat. Moana Miller Before-after, Dressed-undressed. Opioid dependence also produces irritability-like effects that are reversed by CRF receptor antagonists , Effects of d-amphetamine on concurrent self-stimulation of forebrain and brain stem loci. Robust escalation of nicotine intake with extended access to nicotine self-administration and intermittent periods of abstinence.